Chapter 24. Understanding the Role of Water in Nonaqueous Pharmaceutical Systems

  1. Dr. David S. Reid President2,
  2. Dr. Tanaboon Sajjaanantakul3,
  3. Dr. Peter J. Lillford4 and
  4. Dr. Sanguansri Charoenrein5
  1. B. D. Anderson,
  2. S. S. Rane and
  3. T.-X. Xiang

Published Online: 14 MAY 2010

DOI: 10.1002/9780470958193.ch24

Water Properties in Food, Health, Pharmaceutical and Biological Systems: ISOPOW 10

Water Properties in Food, Health, Pharmaceutical and Biological Systems: ISOPOW 10

How to Cite

Anderson, B. D., Rane, S. S. and Xiang, T.-X. (2010) Understanding the Role of Water in Nonaqueous Pharmaceutical Systems, in Water Properties in Food, Health, Pharmaceutical and Biological Systems: ISOPOW 10 (eds D. S. Reid, T. Sajjaanantakul, P. J. Lillford and S. Charoenrein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470958193.ch24

Editor Information

  1. 2

    Department of Food Science and Technology, University of California, Davis, California, USA

  2. 3

    Kasetsart University, Thailand

  3. 4

    Centre for Formulation Engineering, Chemical Engineering, University of Birmingham, Birmingham, UK

  4. 5

    Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok, Thailand

Author Information

  1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA

Publication History

  1. Published Online: 14 MAY 2010
  2. Published Print: 11 JUL 2010

ISBN Information

Print ISBN: 9780813812731

Online ISBN: 9780470958193

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Keywords:

  • understanding - the role of water;
  • water - key contributor to organized local domains formation;
  • heterogeneity, plasticization, higher diffusivity - governing physical, chemical stability;
  • water - determining physicochemical properties;
  • water-water H-bonding interactions - leading to water's structure;
  • dipolar nature of water molecule, electron redistribution - leading to cooperativity in hydrogen-bond formation;
  • chemical stability of API - water acting as nucleophile;
  • common types of moisture uptake - stoichiometric, nonstoichiometric uptake

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Conclusions

  • References