2. Copy Number Variations

  1. Zhanjiang (John) Liu
  1. Jianguo Lu and
  2. Zhanjiang (John) Liu

Published Online: 10 DEC 2010

DOI: 10.1002/9780470958964.ch2

Next Generation Sequencing and Whole Genome Selection in Aquaculture

Next Generation Sequencing and Whole Genome Selection in Aquaculture

How to Cite

Lu, J. and Liu, Z. (2011) Copy Number Variations, in Next Generation Sequencing and Whole Genome Selection in Aquaculture (ed Z. (. Liu), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470958964.ch2

Editor Information

  1. The Fish Molecular Genetics and Biotechnology Laboratory, Department of Fisheries and Allied Aquacultures and Program of Cell and Molecular Biosciences, Aquatic Genomics Unit, Auburn University, Auburn, AL 36849 USA

Author Information

  1. The Fish Molecular Genetics and Biotechnology Laboratory, Department of Fisheries and Allied Aquacultures and Program of Cell and Molecular Biosciences, Aquatic Genomics Unit, Auburn University, Auburn, AL 36849 USA

Publication History

  1. Published Online: 10 DEC 2010
  2. Published Print: 28 JAN 2011

ISBN Information

Print ISBN: 9780813806372

Online ISBN: 9780470958964

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Keywords:

  • Copy number variation (CNV), segment of DNA - copy number differences, two or more genomes;
  • CNVs, and changes in genomic architecture - deletions, insertions and duplications;
  • research on CNVs, lacking - understanding impact of CNVs and its significance in aquaculture;
  • CNVs, influencing genome expression and function - CNV polymorphism influencing performance traits;
  • methods summary, detection of structural variations - in human genome;
  • impact of CNVs on gene expression and phenotypes;
  • array CGH, or molecular karyotyping - techniques to scan genome for gains and losses of chromosomal segments to discover CNVs;
  • genomes, and highly repetitive elements - interfering with hybridization;
  • Multiplex Amplifiable Probe Hybridization (MAPH) - analysis of CNV in targeted genomic regions, based on known information;
  • computational approach, for gene CNVs analysis - among species with reference genome sequences available

Summary

This chapter contains sections titled:

  • Characteristics of CNVs

  • Impact of CNVs on Gene Expression and Phenotypes

  • Methods for CNV Detection and Analysis

  • Genome - wide Association Studies Using CNV

  • References