16. Continuous Chromatographic Separation Technology—Modeling and Simulation

  1. Kai Knoerzer,
  2. Pablo Juliano,
  3. Peter Roupas and
  4. Cornelis Versteeg
  1. Filip Janakievski

Published Online: 16 FEB 2011

DOI: 10.1002/9780470959435.ch16

Innovative Food Processing Technologies: Advances in Multiphysics Simulation

Innovative Food Processing Technologies: Advances in Multiphysics Simulation

How to Cite

Janakievski, F. (2011) Continuous Chromatographic Separation Technology—Modeling and Simulation, in Innovative Food Processing Technologies: Advances in Multiphysics Simulation (eds K. Knoerzer, P. Juliano, P. Roupas and C. Versteeg), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9780470959435.ch16

Editor Information

  1. CSIRO Food and Nutritional Sciences, 671 Sneydes Road, Werribee, VIC 3030, Australia

Author Information

  1. CSIRO Food and Nutritional Sciences, 671 Sneydes Road, Werribee, VIC 3030, Australia

Publication History

  1. Published Online: 16 FEB 2011
  2. Published Print: 25 MAR 2011

ISBN Information

Print ISBN: 9780813817545

Online ISBN: 9780470959435

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Keywords:

  • continuous chromatographic separation technology - modeling and simulation;
  • simulated moving bed (SMB) chromatography - chromatographic technique, countercurrent separation of feed mixture into product streams;
  • SMB chromatography, and food industry - key separation technology for cost-effective isolation of novel ingredients;
  • SMB, and understanding concept of TMB (True Moving Bed) chromatography process;
  • SMB process, overcoming limitations of TMB - retaining continuous countercurrent separation;
  • industrial SMB installations - two groups, based on valve design and operating mode;
  • Sorbex ® process - stationary adsorbent chamber and rotary valve;
  • modeling chromatographic separations - modeling of moving bed processes, TMB and SMB models;
  • SMB model parameter determination - design and optimization of SMB process, and correct operating conditions;
  • biological molecule separation - by continuous countercurrent processes as SMB chromatography

Summary

This chapter contains sections titled:

  • Introduction

  • True Moving Bed (TMB) Chromatography

  • Modeling Chromatographic Separations

  • Column Models

  • Modeling of the SMB process

  • Adsorption Isotherms

  • SMB Design

  • SMB Model Parameter Determination

  • Simulation and Validation

  • Conclusion

  • Notation

  • References