15. We are what we Eat: How Nutritional Compounds Such as Isoflavones Shape Our Epigenome

  1. Mihai D. Niculescu3 and
  2. Paul Haggarty4
  1. Carlos M. Guerrero-Bosagna1 and
  2. Susan J. Clark2

Published Online: 13 APR 2011

DOI: 10.1002/9780470959824.ch15

Nutrition in Epigenetics

Nutrition in Epigenetics

How to Cite

Guerrero-Bosagna, C. M. and Clark, S. J. (2011) We are what we Eat: How Nutritional Compounds Such as Isoflavones Shape Our Epigenome, in Nutrition in Epigenetics (eds M. D. Niculescu and P. Haggarty), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470959824.ch15

Editor Information

  1. 3

    Department of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA

  2. 4

    Nutrition & Epigenetics Group, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen, Scotland, UK

Author Information

  1. 1

    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA

  2. 2

    Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, Sydney, Australia

Publication History

  1. Published Online: 13 APR 2011
  2. Published Print: 27 MAY 2011

ISBN Information

Print ISBN: 9780813816050

Online ISBN: 9780470959824



  • S-adenosyl methionine (SAM);
  • S-adenosylhomocysteine (SAH);
  • selective estrogen receptor modulators (SERMs);
  • epithelial growth factor (EGF);
  • Epigenetics;
  • DNA Methylation and Diseases


This chapter contains sections titled:

  • Introduction

  • Epigenetic Mechanisms of Gene Regulation

  • Nutrition and the Enzymatic Process of DNA Methylation

  • Dietary Flavonoids and Epigenetic Changes

  • A Proposed Mechanism for Endocrine-Mediated Flavonoid Action on Early Mammalian Embryos

  • Epigenetics and Nutritional Epidemiologic Studies

  • DNA Methylation and Diseases

  • Concluding Remarks

  • Acknowledgments

  • References