16. Isothiocyanates and Polyphenols

  1. Mihai D. Niculescu2 and
  2. Paul Haggarty3
  1. Nigel J. Belshaw and
  2. Ian T. Johnson

Published Online: 13 APR 2011

DOI: 10.1002/9780470959824.ch16

Nutrition in Epigenetics

Nutrition in Epigenetics

How to Cite

Belshaw, N. J. and Johnson, I. T. (2011) Isothiocyanates and Polyphenols, in Nutrition in Epigenetics (eds M. D. Niculescu and P. Haggarty), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470959824.ch16

Editor Information

  1. 2

    Department of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA

  2. 3

    Nutrition & Epigenetics Group, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen, Scotland, UK

Author Information

  1. Institute of Food Research, Norwich Research Park, Colney, Norwich, UK

Publication History

  1. Published Online: 13 APR 2011
  2. Published Print: 27 MAY 2011

ISBN Information

Print ISBN: 9780813816050

Online ISBN: 9780470959824



  • Isothiocyanates and Polyphenols;
  • histone deacetylase (HDAC);
  • DNA methyl transferase (DNMT);
  • “spacer-carboxylate”;
  • phenethyl isothiocyanate (PEITC);
  • mitogen-activated protein kinase (MAPK)


This chapter contains sections titled:

  • Introduction

  • Histone Deacetylase Activity of Diallyl Disulfide

  • Histone Deacetylase Activity of Sulforaphane and its Metabolites

  • HDAC Activity of other Isothiocyanates

  • HDAC Activity of Phytoestrogens

  • Phytochemicals and Cell Signaling

  • Conclusion

  • References