11. Application of Proteomics to Elucidate Bacterium–Host Interactions

  1. P. David Eckersall2 and
  2. Phillip D. Whitfield3
  1. David G. E. Smith

Published Online: 5 AUG 2011

DOI: 10.1002/9780470960660.ch11

Methods in Animal Proteomics

Methods in Animal Proteomics

How to Cite

Smith, D. G. E. (2011) Application of Proteomics to Elucidate Bacterium–Host Interactions, in Methods in Animal Proteomics (eds P. D. Eckersall and P. D. Whitfield), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470960660.ch11

Editor Information

  1. 2

    University of Glasgow, UK

  2. 3

    University of the Highlands and Islands, UK

Author Information

  1. Moredun Research Institute, UK

Publication History

  1. Published Online: 5 AUG 2011
  2. Published Print: 19 AUG 2011

ISBN Information

Print ISBN: 9780813817910

Online ISBN: 9780470960660



  • application of proteomics - elucidating bacterium–host interactions;
  • applications of proteomics techniques - to bacterial pathogens, varied;
  • zoonotic bacteria, crossing between host species - and disease in hosts;
  • proteomics analyses, of bacterial protein content - in whole cell preparations;
  • outcome validation - using extended panel of isolates, combined with proteomics, molecular, immunochemical or other approach;
  • surrogate conditions, bacterial (sub)proteome surveys - isolates, cultured in laboratories under “ideal” conditions;
  • stages, bacterial infection of host animal - response to alterations in environmental signals;
  • immunoproteomics - bacterial pathogens and host interaction, and immune response;
  • pathogen–host interaction in vivo - practical challenges, and infection system suitability;
  • pathogenic insult, and cell and tissue alteration - pathogen and host integration, and “omics”


This chapter contains sections titled:

  • Characterizing Bacterial Proteomes

  • Employing Surrogate Conditions

  • Immunoproteomics

  • In Vitro Challenge Systems

  • Pathogen - Host Interaction In Vivo

  • Concluding Comments

  • References