5. Bioinformatics in Animal Proteomics

  1. P. David Eckersall4 and
  2. Phillip D. Whitfield5
  1. Paul Blakeley1,
  2. James C. Wright2,
  3. Simon J. Hubbard1 and
  4. Andrew R. Jones3

Published Online: 5 AUG 2011

DOI: 10.1002/9780470960660.ch5

Methods in Animal Proteomics

Methods in Animal Proteomics

How to Cite

Blakeley, P., Wright, J. C., Hubbard, S. J. and Jones, A. R. (2011) Bioinformatics in Animal Proteomics, in Methods in Animal Proteomics (eds P. D. Eckersall and P. D. Whitfield), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470960660.ch5

Editor Information

  1. 4

    University of Glasgow, UK

  2. 5

    University of the Highlands and Islands, UK

Author Information

  1. 1

    University of Manchester, UK

  2. 2

    Wellcome Trust Sanger Institute, UK

  3. 3

    University of Liverpool, UK

Publication History

  1. Published Online: 5 AUG 2011
  2. Published Print: 19 AUG 2011

ISBN Information

Print ISBN: 9780813817910

Online ISBN: 9780470960660

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Keywords:

  • bioinformatics in animal proteomics - methodologies, analyzing protein sets in complex samples;
  • protein identification in proteomics - by MS, in a single stage;
  • tandem MS, single peptide ion - from MS1 stage, fragmented prior to mass analysis in MS2 stage;
  • genome sequencing, acceleration - new technological developments, “next-generation” sequencers;
  • proteomic data to genome annotation - “proteogenomics”;
  • proteomics analysis pipelines and data repositories - as Genome Annotating Proteomics Pipeline (GAPP) and PeptideAtlas;
  • intron-spanning peptides, unique to specific protein - in proteomic analysis of alternative splicing;
  • proteomic analysis, using - one-dimensional gels, 2D gels and multidimensional protein identification technology [MuDPIT];
  • alternative possibility, and cross-species identification - spectral libraries and profiles;
  • difficulties of applying proteomics - and next-generation sequencing, in easing problems

Summary

This chapter contains sections titled:

  • Introduction

  • Methods

  • Future Trends

  • Sources of Further Information

  • References