5. Inhibition of Protein–Protein Interactions by Peptide Mimics

  1. Ernest Giralt2,
  2. Mark W. Peczuh3 and
  3. Xavier Salvatella4
  1. Jorge Becerril,
  2. Johanna M. Rodriguez,
  3. Pauline N. Wyrembak and
  4. Andrew D. Hamilton

Published Online: 30 NOV 2010

DOI: 10.1002/9780470972137.ch5

Protein Surface Recognition: Approaches for Drug Discovery

Protein Surface Recognition: Approaches for Drug Discovery

How to Cite

Becerril, J., Rodriguez, J. M., Wyrembak, P. N. and Hamilton, A. D. (2010) Inhibition of Protein–Protein Interactions by Peptide Mimics, in Protein Surface Recognition: Approaches for Drug Discovery (eds E. Giralt, M. W. Peczuh and X. Salvatella), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470972137.ch5

Editor Information

  1. 2

    Department of Organic Chemistry, University of Barcelona and Institute for Research in Biomedicine, Barcelona, Spain

  2. 3

    Department of Chemistry, University of Connecticut, Storrs, CT, USA

  3. 4

    ICREA and Institute for Research in Biomedicine, Barcelona, Spain

Author Information

  1. Department of Chemistry, Yale University, New Haven, CT, USA

Publication History

  1. Published Online: 30 NOV 2010
  2. Published Print: 12 NOV 2010

ISBN Information

Print ISBN: 9780470059050

Online ISBN: 9780470972137

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Keywords:

  • protein–protein interaction inhibition - by peptide mimics;
  • biological processes, and communication between proteins - specific surface interactions;
  • protein–protein interactions (PPIs) - normal cell function and regulating processes;
  • β-sheet, second major structural element - in globular proteins;
  • turns, common structural element - in PPIs, post-translational modifications and antibody recognition;
  • inhibitors of protein–protein interactions - allies in fight against HIV-1 epidemic;
  • nuclear estrogen receptor inhibition;
  • coactivator proteins, multiple repeats - conserved Leu-X-X-Leu-Leu (LXXLL) motif;
  • p53/MDM2 interaction, another protein–protein interaction - in apoptotic pathway;
  • protein–protein interactions - mediated by binding epitope, residues as α-helix, β-turn or a β-sheet

Summary

This chapter contains sections titled:

  • Introduction

  • Inhibition of Calmodulin

  • Inhibition of HIV-1 Fusion

  • Inhibition of the Nuclear Estrogen Receptor

  • Inhibition of the Bcl-xL/Bak Interaction

  • Inhibition of the p53/MDM2 Interaction

  • Miscellaneous Protein Targets

  • Conclusion

  • References