4. Examining Gene–Environment Interplay in Psychiatric Disorders

  1. Ming T. Tsuang3,4,
  2. Mauricio Tohen5,6 and
  3. Peter B. Jones7
  1. Judith Allardyce1 and
  2. Jim van Os1,2

Published Online: 14 APR 2011

DOI: 10.1002/9780470976739.ch4

Textbook of Psychiatric Epidemiology, Third Edition

Textbook of Psychiatric Epidemiology, Third Edition

How to Cite

Allardyce, J. and van Os, J. (2011) Examining Gene–Environment Interplay in Psychiatric Disorders, in Textbook of Psychiatric Epidemiology, Third Edition (eds M. T. Tsuang, M. Tohen and P. B. Jones), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470976739.ch4

Editor Information

  1. 3

    Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla CA 92039, USA

  2. 4

    Harvard Institute of Psychiatric Epidemiology & Genetics, Harvard School of Public Health, Boston, USA

  3. 5

    Department of Psychiatry, University of Texas Health Science Centre at San Antonio, USA

  4. 6

    Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7526 Louis Pasteur Drive, San Antonio TX 78229-3900, USA

  5. 7

    Department of Psychiatry, University of Cambridge, Box 189, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK

Author Information

  1. 1

    Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, PO Box 616, Vijverdal, 6200 MD, Maastricht, The Netherlands

  2. 2

    King's College, King's Health Partners, Department of Psychosis Studies, Institute of Psychiatry, London, UK

Publication History

  1. Published Online: 14 APR 2011
  2. Published Print: 15 APR 2011

ISBN Information

Print ISBN: 9780470694671

Online ISBN: 9780470976739

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Keywords:

  • genetic epidemiology;
  • genetic influences;
  • gene–environment interplay;
  • gene–environment correlation;
  • gene–environment interaction;
  • epigenetics;
  • biological interaction;
  • statistical interaction;
  • GEWIS;
  • candidate gene

Summary

Gene environment interplay is recognised as an important biological phenomenon which may provide important aetiological understandings in the study of psychiatric disorders. This chapter (i) provides a description of the different forms of gene environment interplay namely: gene environment correlation, gene–environment interaction, epigenetic processes; (ii) a theoretical overview of models of gene–environment interaction and a discussion about which measurement scale (multiplicative or additive) should be used in statistical analyses; (iii) outlines the designs employed in gene–environment interaction studies and their methodological limitations and (iv) discusses the different approaches to the measurement of the genetic and environment exposures and pathological phenotypes.