1. The Revolution of Real-Time, Label-Free Biosensor Applications

  1. Matthew Cooper2 and
  2. Lorenz M. Mayr3
  1. Rebecca L. Rich and
  2. David G. Myszka

Published Online: 24 FEB 2011

DOI: 10.1002/9780470979129.ch1

Label-Free Technologies for Drug Discovery

Label-Free Technologies for Drug Discovery

How to Cite

Rich, R. L. and Myszka, D. G. (2011) The Revolution of Real-Time, Label-Free Biosensor Applications, in Label-Free Technologies for Drug Discovery (eds M. Cooper and L. M. Mayr), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470979129.ch1

Editor Information

  1. 2

    Institute for Molecular Bioscience, University of Queensland, Australia

  2. 3

    Biology Unit, Protease Platform, Novartis Pharma AG, Basel, Switzerland

Author Information

  1. Center for Biomolecular Interaction Analysis, University of Utah, Salt Lake City, UT 84132, USA

Publication History

  1. Published Online: 24 FEB 2011
  2. Published Print: 25 FEB 2011

ISBN Information

Print ISBN: 9780470746837

Online ISBN: 9780470979129



  • revolution of real-time - label-free biosensor applications;
  • biosensors, as immunosensors - characterizing antibody/antigen interactions;
  • users' understanding - of applying biosensor technology;
  • people's use of biosensors today - users, not aware of use of technology;
  • Super Nintendo Entertainment System - revolutionizing home video gaming, playing sports without going outside;
  • first biosensor release and explosion - variety of commercial biosensors;
  • SPR pessimists, skepticism in scientific community - validity of biosensor data;
  • pharmacia, recognizing advantages - using surface matrix;
  • bad data, and bad reagents, issues to worry - in biosensor experiments, being quality of reagents;
  • data processing and analysis - proper data processing, systematic noise, instrument drift and nonspecific binding


This chapter contains sections titled:

  • Introduction

  • SPR Pessimists

  • Setting Up Experiments

  • Data Processing and Analysis

  • The Good News

  • References