Chapter 11. Steroid-Sparing Strategies: Other Combinations

  1. Ian M. Adcock and
  2. Kian Fan Chung
  1. Gaetano Caramori1,
  2. Kazuhiro Ito2 and
  3. Alberto Papi1

Published Online: 18 MAR 2008

DOI: 10.1002/9780470985731.ch11

Overcoming Steroid Insensitivity in Respiratory Disease

Overcoming Steroid Insensitivity in Respiratory Disease

How to Cite

Caramori, G., Ito, K. and Papi, A. (2008) Steroid-Sparing Strategies: Other Combinations, in Overcoming Steroid Insensitivity in Respiratory Disease (eds I. M. Adcock and K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470985731.ch11

Editor Information

  1. Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK

Author Information

  1. 1

    Centro di Ricerca su Asma e BPCO, Università di Ferrara, Ferrara, Italy

  2. 2

    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK

Publication History

  1. Published Online: 18 MAR 2008
  2. Published Print: 14 MAR 2008

ISBN Information

Print ISBN: 9780470058084

Online ISBN: 9780470985731

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Keywords:

  • cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) levels;
  • airway smooth-muscle relaxation;
  • inhibition of inflammatory cell activation;
  • anti-inflammatory actions of glucocorticoids;
  • Lung oedema and leukocyte adhesion

Summary

This chapter contains sections titled:

  • Introduction

  • Theophylline as steroid-sparing treatment in asthma and COPD

  • Selective inhibitors of PDE4

  • Modulators of the synthesis or action of key inflammatory mediators

  • Anticholinergics

  • Leukotriene synthesis inhibitors and leukotriene receptor antagonists

  • Anti-lgE therapy

  • Macrolides/ketolides

  • TNFα inhibitors

  • Conclusions

  • Acknowledgements

  • References