Chapter 12. Kinases as Anti-Inflammatory Targets for Respiratory Disease

  1. Ian M. Adcock and
  2. Kian Fan Chung
  1. Iain Kilty

Published Online: 18 MAR 2008

DOI: 10.1002/9780470985731.ch12

Overcoming Steroid Insensitivity in Respiratory Disease

Overcoming Steroid Insensitivity in Respiratory Disease

How to Cite

Kilty, I. (2008) Kinases as Anti-Inflammatory Targets for Respiratory Disease, in Overcoming Steroid Insensitivity in Respiratory Disease (eds I. M. Adcock and K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470985731.ch12

Editor Information

  1. Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK

Author Information

  1. Allergy and Respiratory Therapeutic Area, Pfizer Global Research and Development, Sandwich, UK

Publication History

  1. Published Online: 18 MAR 2008
  2. Published Print: 14 MAR 2008

ISBN Information

Print ISBN: 9780470058084

Online ISBN: 9780470985731

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Keywords:

  • cellular signal transduction;
  • population of inflammatory cells;
  • nuclear factor kappa B (NF-κB);
  • inhibitor of kappa B kinases (IKKs);
  • mitogen-activated protein kinases (MAPKs)

Summary

This chapter contains sections titled:

  • Introduction

  • Pharmacological targeting of kinases

  • Targeting NF-κB activation

  • Targeting the MAPKs

  • Targeting PI3K

  • Further potential kinase targets

  • Conclusions

  • Acknowledgements

  • References