Chapter 6. Corticosteroid Responsiveness in Asthma: Clinical Aspects

  1. Ian M. Adcock and
  2. Kian Fan Chung
  1. Kian Fan Chung

Published Online: 18 MAR 2008

DOI: 10.1002/9780470985731.ch6

Overcoming Steroid Insensitivity in Respiratory Disease

Overcoming Steroid Insensitivity in Respiratory Disease

How to Cite

Chung, K. F. (2008) Corticosteroid Responsiveness in Asthma: Clinical Aspects, in Overcoming Steroid Insensitivity in Respiratory Disease (eds I. M. Adcock and K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470985731.ch6

Editor Information

  1. Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK

Author Information

  1. Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK

Publication History

  1. Published Online: 18 MAR 2008
  2. Published Print: 14 MAR 2008

ISBN Information

Print ISBN: 9780470058084

Online ISBN: 9780470985731

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Keywords:

  • introduction of inhaled corticosteroid (ICS) therapy;
  • corticosteroid-resistant (CSR) asthma;
  • corticosteroid sensitive (CSS);
  • glucocorticoid receptor binding;
  • peak expiratory flow rate (PEFR)

Summary

This chapter contains sections titled:

  • Introduction

  • Effects of corticosteroids in asthma

  • Definition of corticosteroid insensitivity

  • Oral CS responsiveness in asthma

  • ICS responsiveness in asthma

  • CS responsiveness in severe asthma

  • Surrogates for CS responsiveness in asthma

  • Pharmacokinetics of systemic CS in severe asthma

  • CS responsiveness in cigarette smokers and chronic obstructive pulmonary disease

  • Other diseases of CS insensitivity

  • Conclusions

  • References