Chapter 7. Glucocorticoid-Insensitive Asthma: Molecular Mechanisms

  1. Ian M. Adcock and
  2. Kian Fan Chung
  1. John W. Bloom

Published Online: 18 MAR 2008

DOI: 10.1002/9780470985731.ch7

Overcoming Steroid Insensitivity in Respiratory Disease

Overcoming Steroid Insensitivity in Respiratory Disease

How to Cite

Bloom, J. W. (2008) Glucocorticoid-Insensitive Asthma: Molecular Mechanisms, in Overcoming Steroid Insensitivity in Respiratory Disease (eds I. M. Adcock and K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470985731.ch7

Editor Information

  1. Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK

Author Information

  1. Departments of Pharmacology and Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA

Publication History

  1. Published Online: 18 MAR 2008
  2. Published Print: 14 MAR 2008

ISBN Information

Print ISBN: 9780470058084

Online ISBN: 9780470985731

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Keywords:

  • Immune activation and tissue inflammation;
  • anti-inflammatory corticosteroids;
  • CS-dependent asthma patients;
  • CS-insensitive asthmatics;
  • inflammatory and anti-inflammatory gene expression

Summary

This chapter contains sections titled:

  • Introduction

  • GR abnormalities

  • GR nuclear translocation

  • Cross-talk with transcription factors

  • NF-κB, GR, histones and chromatin remodelling

  • Epigenetics and asthma

  • Conclusions

  • References