Chapter 26. Anti-Ischemic Drugs

  1. Salim Yusuf1,
  2. John A Cairns2,
  3. A John Camm3,
  4. Ernest L Fallen4 and
  5. Bernard J Gersh5
  1. Lionel H Opie

Published Online: 4 OCT 2007

DOI: 10.1002/9780470986882.ch26

Evidence-based Cardiology, Second Edition

Evidence-based Cardiology, Second Edition

How to Cite

Opie, L. H. (2002) Anti-Ischemic Drugs, in Evidence-based Cardiology, Second Edition (eds S. Yusuf, J. A. Cairns, A. J. Camm, E. L. Fallen and B. J. Gersh), BMJ Books, London, UK. doi: 10.1002/9780470986882.ch26

Editor Information

  1. 1

    Heart and Stroke Foundation of Ontario Research Chair, Senior Scientist of the Canadian Institute of Health Research, Director of Cardiology and Professor of Medicine, McMaster, University, Hamilton Health Sciences, Hamilton, Canada

  2. 2

    Dean, Faculty of Medicine, University of British Columbia, Vancouver, Canada

  3. 3

    Professor of Clinical Cardiology and Chief, Department of Cardiological Sciences, St George's Hospital Medical School, London, UK

  4. 4

    Professor Emeritus, McMaster University, Faculty of Health Sciences, Hamilton, Canada

  5. 5

    Consultant in Cardiovascular Diseases and Internal Medicine, Mayo Clinic; Professor of Medicine, Mayo Medical School, Rochester, Minnesota, USA

Publication History

  1. Published Online: 4 OCT 2007
  2. Published Print: 20 NOV 2002

ISBN Information

Print ISBN: 9780727916990

Online ISBN: 9780470986882



  • anti-ischemic drugs;
  • ischemia;
  • calcium antagonists;
  • β blockers;
  • unstable angina


This chapter contains sections titled:

  • What is ischemia?

  • Safety and efficacy

  • How is safety assessed? The hierarchy of evidence

  • Are there safety concerns regarding calcium antagonists and β blockers?

  • Safety v safe use

  • RCTs

  • Unstable angina as an example of prolonged ischemia

  • Prinzmetal's variant angina

  • Threatened infarction

  • Postinfarct effort angina

  • Ischemic arrhythmias

  • Calcium antagonists in stable angina after angioplasty

  • Congestive heart failure and effort angina

  • ACE inhibitors as potential anti-ischemic drugs

  • Metabolic modifiers

  • Nicorandil

  • Statins as potential anti-ischemic drugs

  • Diuretics as potential anti-ischemic drugs

  • Conclusions