Chapter 57. Diagnosis and Management of Infective Endocarditis

  1. Salim Yusuf1,
  2. John A Cairns2,
  3. A John Camm3,
  4. Ernest L Fallen4 and
  5. Bernard J Gersh5
  1. David T Durack and
  2. Michael L Towns

Published Online: 4 OCT 2007

DOI: 10.1002/9780470986882.ch57

Evidence-based Cardiology, Second Edition

Evidence-based Cardiology, Second Edition

How to Cite

Durack, D. T. and Towns, M. L. (2002) Diagnosis and Management of Infective Endocarditis, in Evidence-based Cardiology, Second Edition (eds S. Yusuf, J. A. Cairns, A. J. Camm, E. L. Fallen and B. J. Gersh), BMJ Books, London, UK. doi: 10.1002/9780470986882.ch57

Editor Information

  1. 1

    Heart and Stroke Foundation of Ontario Research Chair, Senior Scientist of the Canadian Institute of Health Research, Director of Cardiology and Professor of Medicine, McMaster, University, Hamilton Health Sciences, Hamilton, Canada

  2. 2

    Dean, Faculty of Medicine, University of British Columbia, Vancouver, Canada

  3. 3

    Professor of Clinical Cardiology and Chief, Department of Cardiological Sciences, St George's Hospital Medical School, London, UK

  4. 4

    Professor Emeritus, McMaster University, Faculty of Health Sciences, Hamilton, Canada

  5. 5

    Consultant in Cardiovascular Diseases and Internal Medicine, Mayo Clinic; Professor of Medicine, Mayo Medical School, Rochester, Minnesota, USA

Publication History

  1. Published Online: 4 OCT 2007
  2. Published Print: 20 NOV 2002

ISBN Information

Print ISBN: 9780727916990

Online ISBN: 9780470986882



  • infective endocarditis (IE);
  • blood cultures;
  • transesophageal echocardiography;
  • superior sensitivity;
  • transthoracic M-mode echocardiography (TTE)


This chapter contains sections titled:

  • Background

  • Diagnosis

  • What are the optimal blood culture techniques required to diagnose infective endocarditis?

  • Should transesophageal echocardiography be performed in all patients with suspected infective endocarditis?

  • How can the diagnosis of suspected IE be confirmed?

  • Can IE be cured with bacteriostatic antimicrobials?

  • Should combinations of antimicrobials be used to treat IE?

  • What is the optimal duration of treatment for IE?

  • What are the main indications for surgical intervention during management of IE?

  • What is the correct timing for valve replacement during management of IE?

  • Can IE be prevented?