Chapter 6. Non-Steroidal Anti-Inflammatory Drug-Induced Gastroduodenal Toxicity

  1. John WD McDonald1,
  2. Andrew K Burroughs2 and
  3. Brian G Feagan3
  1. Alaa Rostom,
  2. Andreas Maetzel,
  3. Peter Tugwell and
  4. George Wells

Published Online: 25 OCT 2007

DOI: 10.1002/9780470987025.ch6

Evidence-based Gastroenterology and Hepatology, Second Edition

Evidence-based Gastroenterology and Hepatology, Second Edition

How to Cite

Rostom, A., Maetzel, A., Tugwell, P. and Wells, G. (2004) Non-Steroidal Anti-Inflammatory Drug-Induced Gastroduodenal Toxicity, in Evidence-based Gastroenterology and Hepatology, Second Edition (eds J. W. McDonald, A. K. Burroughs and B. G. Feagan), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470987025.ch6

Editor Information

  1. 1

    Professor of Medicine, University of Western Ontario, Gastroenterology Service, London Health Sciences Centre, London, Ontario, Canada

  2. 2

    Consultant Physician/Hepatologist, Royal Free Hospital, London, UK

  3. 3

    Professor of Medicine, University of Western Ontario, Gastroenterology Service, London Health Sciences Centre, London, Ontario, Canada

Publication History

  1. Published Online: 25 OCT 2007
  2. Published Print: 10 NOV 2004

ISBN Information

Print ISBN: 9780727917515

Online ISBN: 9780470987025

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Keywords:

  • gastroduodenal toxicity;
  • non-steroidal anti-inflammatory drugs (NSAIDS);
  • helicobacter pylori;
  • ulcer healing;
  • misoprostol

Summary

This chapter contains sections titled:

  • Introduction

  • Background

  • Risk factors for NSAID-related gastrointestinal toxicity

  • Do endoscopically diagnosed ulcers predict clinical events?

  • The role of Helicobacter pylori in NSAID-associated ulcers

  • Definition of terms

  • Misoprostol

  • H2-receptor antagonists

  • Proton pump inhibitors

  • Summary

  • Cyclo-oxygenase-2 inhibitors

  • Summary