Chapter 26. Products used to Treat Hemophilia: Recombinant Factor VIIa

  1. Christine A. Lee MA, MD, DSc (Med), FRCP, FRCPath1,
  2. Erik E. Berntorp MD, PhD2,
  3. W. Keith Hoots MD3,
  4. Louis M. Aledort MD4
  1. Ulla Hedner

Published Online: 4 OCT 2007

DOI: 10.1002/9780470987124.ch26

Book Title

Textbook of Hemophilia

Textbook of Hemophilia

Additional Information

How to Cite

Hedner, U. (2007) Products used to Treat Hemophilia: Recombinant Factor VIIa, in Textbook of Hemophilia (eds C. A. Lee, E. E. Berntorp, W. K. Hoots and L. M. Aledort), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470987124.ch26

Editor Information

  1. 1

    Professor of Haemophilia, Director and Consultant Haematologist, Haemophilia Centre and Haemostasis Unit, The Royal Free Hospital, London, UK

  2. 2

    Professor of Hemophilia, Lund University;, Director, Department of Coagulation Disorders, Malmö University Hospital, Malmö, Sweden

  3. 3

    Professor of Pediatrics, University of Texas M.D. Anderson Cancer Center;, Professor of Pediatrics and Internal Medicine, University of Texas Medical School at Houston;, Medical Director, Gulf States Hemophilia and Thrombophilia Center, Houston, TX, USA

  4. 4

    The Mary Weinfeld Professor of Clinical Research in Hemophilia, Mount Sinai School of Medicine, New York, NY, USA

Publication History

  1. Published Online: 4 OCT 2007
  2. Published Print: 12 JAN 2005

ISBN Information

Print ISBN: 9781405127691

Online ISBN: 9780470987124

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Keywords:

  • recombinant factor VIIa;
  • bleeding disorders;
  • thrombin generation;
  • thrombin actiactivatable fibrinolytic inhibitor;
  • initiation

Summary

This chapter contains sections titled:

  • Background

  • Mechanism of action of rFVIIa

  • Clinical experience with rFVIIa in hemophilia patients with inhibitors

  • Dosing and monitoring of rFVIIa in hemophilia patients

  • Monitoring of rFVIIa therapy

  • Use of rFVIIa in other bleeding disorders

  • Safety

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