Chapter 13. Woodchuck Hepatitis Virus

  1. Howard Thomas BSc PhD FRCP FRCpath FMedSci Professor1,
  2. Stanley Lemon Professor2 and
  3. Arie Zuckerman MD, DSc, FRCP, FRCPath, FMedSci, Dip. Bact Professor3
  1. Michael Roggendorf and
  2. Michael Lu

Published Online: 26 OCT 2007

DOI: 10.1002/9780470987131.ch13

Viral Hepatitis, Third Edition

Viral Hepatitis, Third Edition

How to Cite

Roggendorf, M. and Lu, M. (2005) Woodchuck Hepatitis Virus, in Viral Hepatitis, Third Edition (eds H. Thomas, S. Lemon and A. Zuckerman), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470987131.ch13

Editor Information

  1. 1

    Dean (Clinical) Faculty of Medicine, Imperial College, Department of Medicine, Queen Elizabeth Queen Mother Wing, St Mary's Hospital Medical School, London UK

  2. 2

    Dean of Medicine, Department of Microbiology & Immunology & Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA

  3. 3

    The Royal Free Hospital of Medicine, Rowland Hill Street, London, UK

Publication History

  1. Published Online: 26 OCT 2007
  2. Published Print: 12 JUL 2005

ISBN Information

Print ISBN: 9781405130059

Online ISBN: 9780470987131



  • woodchuck hepatitis virus;
  • virus-specific T cells;
  • cytokines;
  • incubation period;
  • T-helper epitopes


This chapter contains sections titled:

  • Introduction

  • New tools to characterize the immune response to WHV

  • Cell surface markers

  • Characterization of T-cell response during the incubation period and acute phase of WHV infection

  • Failure of appropriate immune response in the incubation period and early acute infection results in chronic carriership

  • Development of prophylactic and therapeutic vaccines in the woodchuck model

  • What we learnt from the woodchuck model