Chapter 18. Murine Models and Hepatitis B Virus Infection

  1. Howard Thomas BSc PhD FRCP FRCpath FMedSci Professor1,
  2. Stanley Lemon Professor2 and
  3. Arie Zuckerman MD, DSc, FRCP, FRCPath, FMedSci, Dip. Bact Professor3
  1. David R Milich

Published Online: 26 OCT 2007

DOI: 10.1002/9780470987131.ch18

Viral Hepatitis, Third Edition

Viral Hepatitis, Third Edition

How to Cite

Milich, D. R. (2005) Murine Models and Hepatitis B Virus Infection, in Viral Hepatitis, Third Edition (eds H. Thomas, S. Lemon and A. Zuckerman), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470987131.ch18

Editor Information

  1. 1

    Dean (Clinical) Faculty of Medicine, Imperial College, Department of Medicine, Queen Elizabeth Queen Mother Wing, St Mary's Hospital Medical School, London UK

  2. 2

    Dean of Medicine, Department of Microbiology & Immunology & Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA

  3. 3

    The Royal Free Hospital of Medicine, Rowland Hill Street, London, UK

Publication History

  1. Published Online: 26 OCT 2007
  2. Published Print: 12 JUL 2005

ISBN Information

Print ISBN: 9781405130059

Online ISBN: 9780470987131



  • murine models;
  • hepatitis B virus (HBV) infection;
  • HBV proteins;
  • immunogenicity;
  • HBV gene expression


This chapter contains sections titled:

  • Introduction

  • Immunogenicity of HBV proteins studied in mice

  • HBV gene expression and viral replication in Tg mouse models

  • Tg models of HBV pathogenesis and liver injury

  • Tg models of persistence and/or tolerance

  • Modulation of the immune response to HBV proteins in Tg mice

  • Tg mice and hepatocellular carcinoma (HCC)