Chapter 8. Natural History and Experimental Models

  1. Howard Thomas BSc PhD FRCP FRCpath FMedSci Professor1,
  2. Stanley Lemon Professor2 and
  3. Arie Zuckerman MD, DSc, FRCP, FRCPath, FMedSci, Dip. Bact Professor3
  1. Robert H Purcell and
  2. Suzanne U Emerson

Published Online: 26 OCT 2007

DOI: 10.1002/9780470987131.ch8

Viral Hepatitis, Third Edition

Viral Hepatitis, Third Edition

How to Cite

Purcell, R. H. and Emerson, S. U. (2005) Natural History and Experimental Models, in Viral Hepatitis, Third Edition (eds H. Thomas, S. Lemon and A. Zuckerman), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470987131.ch8

Editor Information

  1. 1

    Dean (Clinical) Faculty of Medicine, Imperial College, Department of Medicine, Queen Elizabeth Queen Mother Wing, St Mary's Hospital Medical School, London UK

  2. 2

    Dean of Medicine, Department of Microbiology & Immunology & Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA

  3. 3

    The Royal Free Hospital of Medicine, Rowland Hill Street, London, UK

Publication History

  1. Published Online: 26 OCT 2007
  2. Published Print: 12 JUL 2005

ISBN Information

Print ISBN: 9781405130059

Online ISBN: 9780470987131



  • seroepidemiologic;
  • clinical spectrum;
  • prodromal phase;
  • acute disease;
  • prolonged acute hepatitisa


This chapter contains sections titled:

  • Historical perspectives

  • Clinical features of hepatitis A

  • Outcome of disease

  • Hepatitis A in pregnancy

  • Hepatitis A in pre-existing liver disease

  • Hepatitis A and autoimmune liver disease

  • Hepatitis A and extrahepatic disease

  • Hepatitis A and human immunodeficiency virus (HIV) infection

  • Other associated diseases

  • Histopathology

  • Pathogenesis

  • Animal models of hepatitis A