Chapter 3. Preclinical Safety Testing

  1. John P Griffin BSc, PhD, MBBS, FRCP, FRCPath, FFPM1,
  2. John O'Grady MD, FRCP, FFPM, FBIRA, MRCPath2
  1. David J Tweats

Published Online: 25 OCT 2007

DOI: 10.1002/9780470987391.ch3

Book Title

The Textbook of Pharmaceutical Medicine, Fifth Edition

The Textbook of Pharmaceutical Medicine, Fifth Edition

Additional Information

How to Cite

Tweats, D. J. (2007) Preclinical Safety Testing, in The Textbook of Pharmaceutical Medicine, Fifth Edition (eds J. P. Griffin and J. O'Grady), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470987391.ch3

Editor Information

  1. 1

    Director, Asklepieion Consultancy Ltd., Visiting Professor, University of Surrey Postgraduate Medical School, Former Director, Association of the British Pharmaceutical Industry, London, Formerly Professional Head of the Medicines Division, DHSS, London

  2. 2

    Visiting Professor of Clinical Pharmacology, University of London

Publication History

  1. Published Online: 25 OCT 2007
  2. Published Print: 15 DEC 2005

ISBN Information

Print ISBN: 9780727918406

Online ISBN: 9780470987391

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CHAPTER TOOLS

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Keywords:

  • toxicity;
  • preclinical trials;
  • toxicogenomics;
  • toxicoproteomics;
  • bioinformatics

Summary

This chapter contains sections titled:

  • Introduction

  • Preclinical Safety Pharmacology

  • Single-dose Studies

  • Repeat-dose Studies

  • Oncogenicity Studies

  • Reproductive Toxicology

  • Genotoxicity Testing

  • Irritation and Sensitisation Testing

  • Animal Numbers, Costs and Ethics

  • Acknowledgements

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