Chapter 5. Clinical Pharmacokinetics

  1. John P Griffin BSc, PhD, MBBS, FRCP, FRCPath, FFPM1,
  2. John O'Grady MD, FRCP, FFPM, FBIRA, MRCPath2
  1. Paul Rolan,
  2. Valeria Molnar

Published Online: 25 OCT 2007

DOI: 10.1002/9780470987391.ch5

Book Title

The Textbook of Pharmaceutical Medicine, Fifth Edition

The Textbook of Pharmaceutical Medicine, Fifth Edition

Additional Information

How to Cite

Rolan, P. and Molnar, V. (2007) Clinical Pharmacokinetics, in The Textbook of Pharmaceutical Medicine, Fifth Edition (eds J. P. Griffin and J. O'Grady), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470987391.ch5

Editor Information

  1. 1

    Director, Asklepieion Consultancy Ltd., Visiting Professor, University of Surrey Postgraduate Medical School, Former Director, Association of the British Pharmaceutical Industry, London, Formerly Professional Head of the Medicines Division, DHSS, London

  2. 2

    Visiting Professor of Clinical Pharmacology, University of London

Publication History

  1. Published Online: 25 OCT 2007
  2. Published Print: 15 DEC 2005

ISBN Information

Print ISBN: 9780727918406

Online ISBN: 9780470987391

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CHAPTER TOOLS

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Keywords:

  • pharmacokinetics;
  • absorption, distribution, metabolism and excretion (ADME);
  • drug administration;
  • half-life;
  • bioavailability

Summary

This chapter contains sections titled:

  • Introduction

  • Basic Concepts

  • Bioavailability and Bioequivalence

  • Drug Interactions

  • The Elderly

  • Liver Disease

  • Disposition, Rates and Routes of Elimination of Drug

  • PharmacokineticPharmacodynamic (‘PK/PD’) Modelling

  • Population Analysis

  • The Rest of the Typical Clinical Pharmacokinetics Package

  • The Ideal Drug from the Point of View of Pharmacokinetics

  • The Role of Pharmacokinetic Properties in Determining a Dosage Regimen

  • Summary

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