Chapter 2. What to do When there is no Evidence

  1. Livia Candelise1,
  2. Richard Hughes2,
  3. Alessandro Liberati3,
  4. Bernard M.J. Uitdehaag4 and
  5. Charles Warlow5
  1. Charles Warlow

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988350.ch2

Evidence-based Neurology: Management of Neurological Disorders

Evidence-based Neurology: Management of Neurological Disorders

How to Cite

Warlow, C. (2007) What to do When there is no Evidence, in Evidence-based Neurology: Management of Neurological Disorders (eds L. Candelise, R. Hughes, A. Liberati, B. M.J. Uitdehaag and C. Warlow), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470988350.ch2

Editor Information

  1. 1

    Cochrane Neurological Network, Ospedale Magglore Policlinico, University of Milan, Italy

  2. 2

    King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, UK

  3. 3

    Università di Modena e Reggio Emillia, Modena, Italy

  4. 4

    VU University Medical Center, Amsterdam, The Netherlands

  5. 5

    University of Edinburgh, Western General Hospital, Edinburgh, UK

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9780727918116

Online ISBN: 9780470988350

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Keywords:

  • evidence-based medicine EBM;
  • non-randomized evidence;
  • pathophysiology;
  • therapeutic nihilism;
  • clinical trial

Summary

This chapter contains sections titled:

  • Do not succumb to EBMitis

  • Are you absolutely sure there is no evidence?

  • Can you generalize from what evidence there is?

  • Can you use non-randomized evidence from good observational studies?

  • What about relying on pathophysiology?

  • Is there such a thing as clinical wisdom?

  • Join a clinical trial

  • Remain humble, do not succumb to therapeutic nihilism or the company dinner