Chapter 1. Endothelial Functions and Dysfunctions

  1. Raffaele De Caterina MD, PhD1,2 and
  2. Peter Libby MD3
  1. Raffaele De Caterina MD, PhD,
  2. Marika Massaro DBiol, PhD and
  3. Peter Libby MD

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988473.ch1

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease

How to Cite

De Caterina, R., Massaro, M. and Libby, P. (2007) Endothelial Functions and Dysfunctions, in Endothelial Dysfunctions in Vascular Disease (eds R. De Caterina and P. Libby), Blackwell Publishing, Oxford, UK. doi: 10.1002/9780470988473.ch1

Editor Information

  1. 1

    Professor of Cardiology, Chair and Postgraduate School of Cardiology; “G. d'Annunzio” University - Chieti, Ospedale San Camillo de Lellis; Via C. Forlanni, 50, 66100 Chieti

  2. 2

    Director, Laboratory for Thrombosis and Vascular Research; CNR Institute of Clinical Physiology, Area della Ricerca di S. Cataldo; Via G.Moruzzi, 1, 56124 Pisa, Italy

  3. 3

    Mallinckrodt Professor, Harvard Medical School and Chief, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122085

Online ISBN: 9780470988473



  • endothelial cells;
  • vascular homeostasis;
  • vasoregulatory substances;
  • endothelins;
  • nitric oxide


This chapter contains sections titled:

  • Introduction

  • Dysfunctional and activated endothelium: definitions

  • Endothelial cell morphology

  • Barrier function of the endothelium

  • Endothelial regulation of vascular tone

  • The endothelial control of hemostasis

  • Control of leukocyte traffic during inflammatory reactions

  • Role of transcriptional factor NFκB in endothelial dysfunction

  • General conclusions