Chapter 10. Oxidative Stress and Vascular Disease

  1. Raffaele De Caterina MD, PhD1,2 and
  2. Peter Libby MD3
  1. Dominik Behrendt MD and
  2. Peter Ganz MD

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988473.ch10

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease

How to Cite

Behrendt, D. and Ganz, P. (2007) Oxidative Stress and Vascular Disease, in Endothelial Dysfunctions in Vascular Disease (eds R. De Caterina and P. Libby), Blackwell Publishing, Oxford, UK. doi: 10.1002/9780470988473.ch10

Editor Information

  1. 1

    Professor of Cardiology, Chair and Postgraduate School of Cardiology; “G. d'Annunzio” University - Chieti, Ospedale San Camillo de Lellis; Via C. Forlanni, 50, 66100 Chieti

  2. 2

    Director, Laboratory for Thrombosis and Vascular Research; CNR Institute of Clinical Physiology, Area della Ricerca di S. Cataldo; Via G.Moruzzi, 1, 56124 Pisa, Italy

  3. 3

    Mallinckrodt Professor, Harvard Medical School and Chief, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122085

Online ISBN: 9780470988473



  • oxidative stress;
  • vascular disease;
  • reactive oxygen species;
  • low density lipoproteins;
  • free radicals


This chapter contains sections titled:

  • Oxidative stress

  • Involvement of ROS in the pathogenesis of vascular disease

  • Sources of ROS

  • Vascular endothelium and NO

  • Oxidative stress and endothelial dysfunction

  • Endothelial vasomotor function

  • Endothelial vasomotor dysfunction and oxidative stress

  • Oxidant stress and inflammation

  • Oxidant stress and the vulnerable plaque

  • Oxidative stress and restenosis

  • Clinical outcome studies of antioxidant vitamins