Chapter 15. Endothelial Vasodilatory Dysfunction in Hypertension

  1. Raffaele De Caterina MD, PhD1,2 and
  2. Peter Libby MD3
  1. Umberto Campia MD and
  2. Julio A. Panza MD

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988473.ch15

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease

How to Cite

Campia, U. and Panza, J. A. (2007) Endothelial Vasodilatory Dysfunction in Hypertension, in Endothelial Dysfunctions in Vascular Disease (eds R. De Caterina and P. Libby), Blackwell Publishing, Oxford, UK. doi: 10.1002/9780470988473.ch15

Editor Information

  1. 1

    Professor of Cardiology, Chair and Postgraduate School of Cardiology; “G. d'Annunzio” University - Chieti, Ospedale San Camillo de Lellis; Via C. Forlanni, 50, 66100 Chieti

  2. 2

    Director, Laboratory for Thrombosis and Vascular Research; CNR Institute of Clinical Physiology, Area della Ricerca di S. Cataldo; Via G.Moruzzi, 1, 56124 Pisa, Italy

  3. 3

    Mallinckrodt Professor, Harvard Medical School and Chief, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122085

Online ISBN: 9780470988473



  • hypertension;
  • vascular homeostasis;
  • nitric oxide;
  • muscarinic receptor defects;
  • endothelial dysfunction


This chapter contains sections titled:

  • Introduction

  • Investigational techniques to assess endothelial function

  • Endothelial vasodilatory dysfunction in hypertension and nitric oxide

  • Abnormal NO bioactivity in hypertension: potential mechanisms

  • The endothelin system: endothelial dysfunction in hypertension extends beyond impaired endotheliumdependent dilation

  • NO and ET-1 interactions in hypertension: endothelial dysfunction at the crossroad of the two systems

  • Hypertension, obesity, and the endothelin system

  • Hypertension, ethnicity, and the endothelin system

  • Endothelial progenitor cells: a new link between hypertension and endothelial dysfunction?

  • Shear stress and microvascular endothelial function in hypertension

  • Endothelial dysfunction in hypertension: cause or consequence of elevated blood pressure?

  • Impaired endotheliumdependent dilation of conduit vessels: the link between hypertension and atherosclerosis?

  • PPARγ: the link between insulin resistance, hypertension, and endothelial dysfunction?

  • Prognostic value of endothelial dysfunction in hypertension

  • Effect of antihypertensive treatment on endothelial function