Chapter 17. Dyslipidemia and Endothelial Dysfunction: Pathophysiology and Therapy

  1. Raffaele De Caterina MD, PhD1,2 and
  2. Peter Libby MD3
  1. Todd J. Anderson MD, FRCPC and
  2. Francois Charbonneau MSC, MD

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988473.ch17

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease

How to Cite

Anderson, T. J. and Charbonneau, F. (2007) Dyslipidemia and Endothelial Dysfunction: Pathophysiology and Therapy, in Endothelial Dysfunctions in Vascular Disease (eds R. De Caterina and P. Libby), Blackwell Publishing, Oxford, UK. doi: 10.1002/9780470988473.ch17

Editor Information

  1. 1

    Professor of Cardiology, Chair and Postgraduate School of Cardiology; “G. d'Annunzio” University - Chieti, Ospedale San Camillo de Lellis; Via C. Forlanni, 50, 66100 Chieti

  2. 2

    Director, Laboratory for Thrombosis and Vascular Research; CNR Institute of Clinical Physiology, Area della Ricerca di S. Cataldo; Via G.Moruzzi, 1, 56124 Pisa, Italy

  3. 3

    Mallinckrodt Professor, Harvard Medical School and Chief, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122085

Online ISBN: 9780470988473

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Keywords:

  • dyslipidemia;
  • endothelial dysfunction;
  • acute coronary syndromes;
  • low-density lipoproteins;
  • lipids

Summary

This chapter contains sections titled:

  • Lipids and endothelial function

  • Pathophysiology of lipid-induced endothelial dysfunction

  • Cholesterol and oxidative stress

  • Cholesterol, oxidative stress, and NO bioactivity

  • Cholesterol and other vasoactive substances

  • Lipids and inflammatory mediators

  • Beneficial vascular effects of lipid lowering

  • Treatment of lipid-induced endothelial dysfunction in humans

  • Conclusion

  • Acknowledgments