Chapter 21. Treatment of Endothelial Dysfunction and Atherosclerosis by Cholesterol Lowering

  1. Raffaele De Caterina MD, PhD1,2 and
  2. Peter Libby MD3
  1. Masanori Aikawa MD, PhD and
  2. Peter Libby MD

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988473.ch21

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease

How to Cite

Aikawa, M. and Libby, P. (2007) Treatment of Endothelial Dysfunction and Atherosclerosis by Cholesterol Lowering, in Endothelial Dysfunctions in Vascular Disease (eds R. De Caterina and P. Libby), Blackwell Publishing, Oxford, UK. doi: 10.1002/9780470988473.ch21

Editor Information

  1. 1

    Professor of Cardiology, Chair and Postgraduate School of Cardiology; “G. d'Annunzio” University - Chieti, Ospedale San Camillo de Lellis; Via C. Forlanni, 50, 66100 Chieti

  2. 2

    Director, Laboratory for Thrombosis and Vascular Research; CNR Institute of Clinical Physiology, Area della Ricerca di S. Cataldo; Via G.Moruzzi, 1, 56124 Pisa, Italy

  3. 3

    Mallinckrodt Professor, Harvard Medical School and Chief, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122085

Online ISBN: 9780470988473

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Keywords:

  • hypercholesterolemia;
  • vascular inflammation;
  • endothelial dysfunction;
  • oxidative stress;
  • low-density lipoprotein cholesterol

Summary

This chapter contains sections titled:

  • Introduction

  • Hypercholesterolemia as a major coronary risk factor

  • Oxidative stress induces atherogenic molecules and suppresses antiatherogenic molecules in EC

  • The role of macrophages in acute thrombotic complications

  • The role of EC dysfunction in acute coronary syndromes

  • Cholesterol lowering by HMG-CoA reductase inhibitors prevents acute coronary syndromes

  • Cholesterol lowering improves atheroma biology associated with plaque vulnerability and thrombogenicity

  • Cholesterol lowering improves oxidative stress and EC dysfunction in atherosclerotic plaques

  • Cholesterol lowering vs direct effects of statins on EC dysfunction

  • Conclusions and the future perspectives

  • Acknowledgment