Chapter 24. PPARs in Atherosclerosis

  1. Raffaele De Caterina MD, PhD1,2 and
  2. Peter Libby MD3
  1. Ouliana Ziouzenkova PhD,
  2. Nikolaus Marx MD,
  3. Peter Libby MD and
  4. Jorge Plutzky MD

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988473.ch24

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease

How to Cite

Ziouzenkova, O., Marx, N., Libby, P. and Plutzky, J. (2007) PPARs in Atherosclerosis, in Endothelial Dysfunctions in Vascular Disease (eds R. De Caterina and P. Libby), Blackwell Publishing, Oxford, UK. doi: 10.1002/9780470988473.ch24

Editor Information

  1. 1

    Professor of Cardiology, Chair and Postgraduate School of Cardiology; “G. d'Annunzio” University - Chieti, Ospedale San Camillo de Lellis; Via C. Forlanni, 50, 66100 Chieti

  2. 2

    Director, Laboratory for Thrombosis and Vascular Research; CNR Institute of Clinical Physiology, Area della Ricerca di S. Cataldo; Via G.Moruzzi, 1, 56124 Pisa, Italy

  3. 3

    Mallinckrodt Professor, Harvard Medical School and Chief, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122085

Online ISBN: 9780470988473



  • peroxisome proliferator-activated receptors;
  • atherosclerosis;
  • fatty acid metabolism;
  • coronary heart disease;
  • low-density lipoproteins


This chapter contains sections titled:

  • PPARs: ligand-activated transcriptions implicated in metabolism, inflammation, and atherosclerosis

  • PPARs: basic mechanisms

  • PPAR-α: a central mediator of fatty acid metabolism

  • PPAR-γ: key mediator of adipogenesis, lipid metabolism, and glucose control

  • Integrating PPAR biology into vascular biology: an evolving perspective