Chapter 7. Advanced Glycation Endproducts and the Accelerated Atherosclerosis in Diabetes

  1. Raffaele De Caterina MD, PhD1,2 and
  2. Peter Libby MD3
  1. Giuseppina Basta DBiol,
  2. Ann Marie Schmidt MD and
  3. Raffaele De Caterina MD, PhD

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988473.ch7

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease

How to Cite

Basta, G., Schmidt, A. M. and De Caterina, R. (2007) Advanced Glycation Endproducts and the Accelerated Atherosclerosis in Diabetes, in Endothelial Dysfunctions in Vascular Disease (eds R. De Caterina and P. Libby), Blackwell Publishing, Oxford, UK. doi: 10.1002/9780470988473.ch7

Editor Information

  1. 1

    Professor of Cardiology, Chair and Postgraduate School of Cardiology; “G. d'Annunzio” University - Chieti, Ospedale San Camillo de Lellis; Via C. Forlanni, 50, 66100 Chieti

  2. 2

    Director, Laboratory for Thrombosis and Vascular Research; CNR Institute of Clinical Physiology, Area della Ricerca di S. Cataldo; Via G.Moruzzi, 1, 56124 Pisa, Italy

  3. 3

    Mallinckrodt Professor, Harvard Medical School and Chief, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122085

Online ISBN: 9780470988473

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Keywords:

  • advanced glycation endproducts;
  • atherosclerosis;
  • diabetes;
  • low density lipoproteins;
  • extracellular matrix

Summary

This chapter contains sections titled:

  • Introduction

  • Biochemical mechanisms leading to AGE production

  • How AGE promote atherosclerosis: molecular mechanisms

  • Non-receptor-mediated effects of AGE on atherogenesis

  • Receptor-mediated effects of AGE in atherogenesis

  • AGE and RAGE in experimental animals

  • AGE, RAGE, and vascular dysfunction in humans: possible therapeutic interventions on AGE formation, AGE cross-linking and AGE-RAGE interaction

  • Conclusions