Chapter 8. Homocysteine and Endothelial Dysfunction

  1. Raffaele De Caterina MD, PhD1,2 and
  2. Peter Libby MD3
  1. Rosalinda Madonna MD, PhD and
  2. Raffaele De Caterina MD, PhD

Published Online: 12 NOV 2007

DOI: 10.1002/9780470988473.ch8

Endothelial Dysfunctions in Vascular Disease

Endothelial Dysfunctions in Vascular Disease

How to Cite

Madonna, R. and De Caterina, R. (2007) Homocysteine and Endothelial Dysfunction, in Endothelial Dysfunctions in Vascular Disease (eds R. De Caterina and P. Libby), Blackwell Publishing, Oxford, UK. doi: 10.1002/9780470988473.ch8

Editor Information

  1. 1

    Professor of Cardiology, Chair and Postgraduate School of Cardiology; “G. d'Annunzio” University - Chieti, Ospedale San Camillo de Lellis; Via C. Forlanni, 50, 66100 Chieti

  2. 2

    Director, Laboratory for Thrombosis and Vascular Research; CNR Institute of Clinical Physiology, Area della Ricerca di S. Cataldo; Via G.Moruzzi, 1, 56124 Pisa, Italy

  3. 3

    Mallinckrodt Professor, Harvard Medical School and Chief, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 12 NOV 2007
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122085

Online ISBN: 9780470988473



  • homocysteine;
  • cardiovascular disease;
  • hyperhomocysteinemia;
  • flavin adenine dinucleotide;
  • cellular toxicity


This chapter contains sections titled:

  • Introduction

  • Terminology, biochemistry, distribution, and metabolism of homocysteine

  • Normal and pathological levels of homocysteine: classification and incidence of hyperhomocysteinemia

  • Homocysteine, endothelial dysfunction, and atherosclerosis

  • Evidence for in vivo effects of homocysteine

  • Conclusions