Chapter 51. A Comprehensive Model for O2 Constriction in the Human Ductus Arteriosus

  1. Michael Artman MD1,
  2. D. Woodrow Benson MD, PhD2,
  3. Deepak Srivastava MD3 and
  4. Makoto Nakazawa MD4
  1. Evangelos D. Michelakis,
  2. Bernard Thébaud,
  3. Xi-Chen Wu,
  4. Kyoko Hashimoto,
  5. Rohit Moudgil,
  6. Gwyneth Harry,
  7. Ivan M. Rebeyka and
  8. Stephen L. Archer

Published Online: 16 NOV 2007

DOI: 10.1002/9780470988664.ch51

Cardiovascular Development and Congenital Malformations: Molecular & Genetic Mechanisms

Cardiovascular Development and Congenital Malformations: Molecular & Genetic Mechanisms

How to Cite

Michelakis, E. D., Thébaud, B., Wu, X.-C., Hashimoto, K., Moudgil, R., Harry, G., Rebeyka, I. M. and Archer, S. L. (2005) A Comprehensive Model for O2 Constriction in the Human Ductus Arteriosus, in Cardiovascular Development and Congenital Malformations: Molecular & Genetic Mechanisms (eds M. Artman, D. W. Benson, D. Srivastava and M. Nakazawa), Blackwell Publishing Ltd, Malden, Massachusetts, USA. doi: 10.1002/9780470988664.ch51

Editor Information

  1. 1

    Chairman of Pediatrics University of Iowa

  2. 2

    Professor of Pediatrics, Director, Cardiovascular Genetics, Division of Cardiology, Cincinnati Children's Hospital Medical Center

  3. 3

    Pogue Distinguished Chair in Research on Cardiac Birth Defects, Joel B. Steinberg, M.D. Chair in Pediatrics Professor, Departments of Pediatrics and Molecular Biology, University of Texas, Southwestern Medical Center at Dallas

  4. 4

    Professor and Head, Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University

Publication History

  1. Published Online: 16 NOV 2007
  2. Published Print: 1 JAN 2005

ISBN Information

Print ISBN: 9781405131285

Online ISBN: 9780470988664

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Keywords:

  • ductus arteriosus (DA);
  • cell proliferation;
  • cardiac shunt;
  • congenital heart disease;
  • mortality rates

Summary

This chapter contains sections titled:

  • Introduction

  • Endothelin modulates DA tone

  • K+ channels and constriction of the DA

  • O2 sensing, mitochondria and redox sensitive K+ channels in the DASMC