Regulation of Laminar and Area Patterning of Mammalian Neocortex and Behavioural Implications

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. Dennis D. M. O'Leary1,2,
  2. Shen-Ju Chou2,
  3. Tadashi Hamasaki2,†,
  4. Setsuko Sahara2,
  5. Akihide Takeuchi2,‡,
  6. Sandrine Thuret2,§ and
  7. Axel Leingärtner2

Published Online: 1 FEB 2008

DOI: 10.1002/9780470994030.ch11

Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288

Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288

How to Cite

O'Leary, D. D. M., Chou, S.-J., Hamasaki, T., Sahara, S., Takeuchi, A., Thuret, S. and Leingärtner, A. (2008) Regulation of Laminar and Area Patterning of Mammalian Neocortex and Behavioural Implications, in Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470994030.ch11

Author Information

  1. 1

    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA

  2. 2

    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 96037, USA

  1. Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan

  2. Department of Functional Genomics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan

  3. §

    Centre for the Cellular Basis of Behaviour & MRC Centre for Neurodegeneration Research The James Black Centre, King's College London Institute of Psychiatry, London SE5 9NU, UK

Publication History

  1. Published Online: 1 FEB 2008
  2. Published Print: 11 JAN 2008

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470060926

Online ISBN: 9780470994030

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Keywords:

  • area patterning;
  • cortical hem;
  • commissural plate;
  • COUP-TFI;
  • Emx2;
  • Fgf8;
  • MDGA1;
  • Pax6;
  • Sp8;
  • time-lapse imaging

Summary

We will focus on describing our recent studies on the laminar and area patterning of the mammalian neocortex. We describe a novel IgCAM, MDGA1, that is a unique laminar and area specific marker, and functional studies showing its influence on radial migration. We also describe time-lapse imaging studies showing that the preplate and its derivative, the subplate, is a cellular protomap of the cortical ventricular zone, and the implications of this finding for mechanisms of arealization and development of area-specific TCA projections. We will summarize studies of each of the four transcription factors, Emx2, Pax6, Couptf1 and Sp8, expressed by cortical progenitors and involved in specifying area patterning. Finally, we will describe studies showing that area size dictates performance at modality-specific behaviours.