Genetic Regulation of Prefrontal Cortex Development and Function

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. Jeremy A. Cholfin1,2 and
  2. John L. R. Rubenstein2,†

Published Online: 1 FEB 2008

DOI: 10.1002/9780470994030.ch12

Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288

Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288

How to Cite

Cholfin, J. A. and Rubenstein, J. L. R. (2008) Genetic Regulation of Prefrontal Cortex Development and Function, in Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470994030.ch12

Author Information

  1. 1

    Medical Scientist Training Program, Neuroscience Graduate Program, University of California, San Francisco, CA 94143-2611, USA

  2. 2

    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, Department of Psychiatry, 1550 4th Street, 2nd Floor South, Room RH 284C, Box 2611, San Francisco, CA 94143-2611, USA

  1. This paper was presented at the symposium by John Rubenstein, to whom correspondence should be addressed.

Publication History

  1. Published Online: 1 FEB 2008
  2. Published Print: 11 JAN 2008

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470060926

Online ISBN: 9780470994030

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Keywords:

  • fibroblast growth factor;
  • FGF;
  • cortex;
  • prefrontal cortex;
  • patterning;
  • regionalization

Summary

The prefrontal cortex (PFC) consists of multiple areas that mediate a wide range of higher-order behaviours in mammals. Despite years of intensive neuroanatomical and functional studies, little is known about the genetic mechanisms that pattern this structure during development. It has been recognized that fibroblast growth factor (FGF) signalling from the rostral patterning centre could have a central role in regulating rostral telencephalic development. A subset of FGF genes are expressed in the rostral patterning centre in the embryonic telencephalon. Recent evidence shows that FGFs, including Fgf17, regulate the graded expression of regulatory genes in the cortical neuroepithelium, which may specify the initial distribution of PFC regional subdivisions and ultimately mature areas.