Genetic Determinants of Neuronal Migration in the Cerebral Cortex

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. Pasko Rakic,
  2. Kazue Hashimoto-Torii and
  3. Matthew R. Sarkisian

Published Online: 1 FEB 2008

DOI: 10.1002/9780470994030.ch4

Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288

Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288

How to Cite

Rakic, P., Hashimoto-Torii, K. and Sarkisian, M. R. (2008) Genetic Determinants of Neuronal Migration in the Cerebral Cortex, in Cortical Development: Genes and Genetic Abnormalities: Novartis Foundation Symposium 288 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470994030.ch4

Author Information

  1. Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, 333 Cedar Street, SHM C303, PO Box 208001, New Haven, CT 06520-8001, USA

Publication History

  1. Published Online: 1 FEB 2008
  2. Published Print: 11 JAN 2008

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470060926

Online ISBN: 9780470994030

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Keywords:

  • neocortex;
  • neuronal migration;
  • radial glial cells;
  • numb;
  • Filamin-A;
  • MEKK4;
  • reelin;
  • Notch

Summary

The techniques and concepts of modern molecular biology and experimental neurobiology give new insights into molecular mechanisms involved in neuronal migration within the cerebral cortex. The findings collectively indicate that a diverse family of genes and transcription factors co-operate in orchestrating the multistage, interrelated phenomena that include control of mode of cell proliferation, fate determination, establishment of polarity, detachment from the local substrate and migration to the proper laminar and areal position in the cortex. Herein, we will review some new data from our laboratory on the initiation of migration, nuclear translocation and attainment of final positions. We can now propose working models of the sequence of gene expression, cascade of multiple molecular pathways and cell–cell interactions that are involved in neuronal migration. Disruption or even slowing down of any step in neuronal migration during embryonic development can result in either gross or subtle abnormalities in neuronal positioning that may only later, during postnatal life, affect the formation of synaptic circuits and eventually behaviour.