13. The Epigenome and Its Relevance to Somatic Cell Nuclear Transfer and Nuclear Reprogramming

  1. Zhihua Jiang2 and
  2. Troy L. Ott3
  1. Jorge A. Piedrahita,
  2. Steve Bischoff and
  3. Shengdar Tsai

Published Online: 6 APR 2010

DOI: 10.1002/9780813810898.ch13

Reproductive Genomics in Domestic Animals

Reproductive Genomics in Domestic Animals

How to Cite

Piedrahita, J. A., Bischoff, S. and Tsai, S. (2010) The Epigenome and Its Relevance to Somatic Cell Nuclear Transfer and Nuclear Reprogramming, in Reproductive Genomics in Domestic Animals (eds Z. Jiang and T. L. Ott), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813810898.ch13

Editor Information

  1. 2

    Department of Animal Sciences, Center for Reproductive Biology, Washington State University, Pullman, WA 99164-6351, USA

  2. 3

    Department of Dairy and Animal Sciences, Center for Reproductive Biology and Health, The Pennsylvania State University, University Park, PA 16802, USA

Author Information

  1. Department of Molecular Biomedical Sciences and Center of Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA

Publication History

  1. Published Online: 6 APR 2010
  2. Published Print: 14 MAY 2010

ISBN Information

Print ISBN: 9780813817842

Online ISBN: 9780813810898

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Keywords:

  • epigenome - and somatic cell nuclear transfer and nuclear reprogramming;
  • epigenetics phenomenon - change in phenotype without change in genotype;
  • DNA methylation and DNA methyl transferases;
  • ICRs - imprinting regional control centers;
  • differentially methylated DNA regions (DMRs) - germline imprinting;
  • angiogenesis - placental development and function;
  • mammalian methylating DNA enzyme types

Summary

This chapter contains sections titled:

  • Introduction

  • The epigenome

  • Epigenetic reprogramming

  • Genomic imprinting

  • SCNT and epigenetic abnormalities

  • Future research directions

  • References