1. Antioxidant Activity and Oxidative Stress: An Overview

  1. Giancarlo Aldini1,
  2. Kyung-Jin Yeum2,
  3. Etsuo Niki3 and
  4. Robert M. Russell4
  1. Kyung-Jin Yeum2,
  2. Robert M. Russell4 and
  3. Giancarlo Aldini1

Published Online: 4 AUG 2010

DOI: 10.1002/9780813814438.ch1

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

How to Cite

Yeum, K.-J., Russell, R. M. and Aldini, G. (2010) Antioxidant Activity and Oxidative Stress: An Overview, in Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (eds G. Aldini, K.-J. Yeum, E. Niki and R. M. Russell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813814438.ch1

Editor Information

  1. 1

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 2

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 3

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

  4. 4

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Author Information

  1. 1

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 2

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 4

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Publication History

  1. Published Online: 4 AUG 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9780813815350

Online ISBN: 9780813814438

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Keywords:

  • antioxidant defense and oxidative damage biomarkers;
  • oxidative stress and aging process;
  • reactive oxygen/nitrogen species (ROS/RNS) - antioxidant and oxidant imbalance causing oxidative damage;
  • sensitive and specific biomarkers for antioxidant status/oxidative stress - and role of antioxidants;
  • actions of antioxidants in biological systems – oxidant nature or ROS imposed on biological systems;
  • oxidative stress and antioxidants - in biological systems;
  • markers of antioxidant capacity - in biological system;
  • total radical trapping antioxidant parameter (TRAP) and oxygen radical absorbance capacity (ORAC);
  • hydrophilic antioxidant capacity assays;
  • optimal ranges of antioxidants - balanced dietary fruit and vegetable intake, high doses leading to a pro-oxidant effect

Summary

This chapter contains sections titled:

  • Introduction

  • Oxidative Stress and Antioxidants in a Biological System

  • Markers of Antioxidant Capacity in a Biological System

  • Biological Significance of Antioxidant Interactions

  • Biological Relevance of Antioxidant Supplementation

  • Antioxidants and Gene Interactions

  • Summary

  • Acknowledgement

  • References