13. Ubiquitin Conjugates: A Sensitive Marker of Oxidative Stress

  1. Giancarlo Aldini2,
  2. Kyung-Jin Yeum3,
  3. Etsuo Niki4 and
  4. Robert M. Russell5
  1. Fu Shang and
  2. Allen Taylor

Published Online: 4 AUG 2010

DOI: 10.1002/9780813814438.ch13

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

How to Cite

Shang, F. and Taylor, A. (2010) Ubiquitin Conjugates: A Sensitive Marker of Oxidative Stress, in Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (eds G. Aldini, K.-J. Yeum, E. Niki and R. M. Russell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813814438.ch13

Editor Information

  1. 2

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 3

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 4

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

  4. 5

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Author Information

  1. Jean Mayer USDA—Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA

Publication History

  1. Published Online: 4 AUG 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9780813815350

Online ISBN: 9780813814438

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Keywords:

  • ubiquitin conjugates, sensitive marker of oxidative stress;
  • ubiquitin function, tagging proteins for degradation by ubiquitin-proteasome pathway (UPP);
  • UPP, important protein quality control system;
  • ubiquitin-protein conjugate formation - prerequisite for UPP degradation;
  • levels of ubiquitin conjugates, in response to oxidative stressors in cells and tissues;
  • lipofuscin exposure - and mediated photooxidation;
  • endogenous ubiquitin conjugate levels - by western blotting;
  • ubiquitin conjugates - in response to oxidative stress;
  • radiomimetic neocarzinostatin, anticancer drug - inducing DNA double strand breaks and protein damage;
  • UPP, role in cellular functions - protein quality control and signal transduction

Summary

This chapter contains sections titled:

  • Introduction

  • Materials and Methods

  • Results

  • Conclusion

  • Technical Details and Cautions

  • Acknowledgments

  • References