18. Exocyclic DNA Adducts as Biomarkers of Antioxidant Defense and Oxidative Stress

  1. Giancarlo Aldini2,
  2. Kyung-Jin Yeum3,
  3. Etsuo Niki4 and
  4. Robert M. Russell5
  1. Roger W. L. Godschalk

Published Online: 4 AUG 2010

DOI: 10.1002/9780813814438.ch18

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

How to Cite

Godschalk, R. W. L. (2010) Exocyclic DNA Adducts as Biomarkers of Antioxidant Defense and Oxidative Stress, in Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (eds G. Aldini, K.-J. Yeum, E. Niki and R. M. Russell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813814438.ch18

Editor Information

  1. 2

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 3

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 4

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

  4. 5

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Author Information

  1. Department of Health Risk Analysis and Toxicology, Maastricht University, Universiteissingel 50, 6200MD Maastricht, The Netherlands

Publication History

  1. Published Online: 4 AUG 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9780813815350

Online ISBN: 9780813814438

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Keywords:

  • exocyclic DNA adducts - as antioxidant defense and oxidative stress biomarkers;
  • chronic inflammation, linked to malignant disease development in tissues;
  • chronic inflammation, persistent oxidative stress and lipid peroxidation (LPO) excess;
  • biomarker use in epidemiological settings - molecular epidemiology;
  • sensitive and highly specific methods - detecting and quantifying exocyclic DNA adducts in human and animal tissues;
  • knowledge of dose-response relationships and adduct persistence - for exposure monitoring studies and interventions;
  • sources of inter- and intra-individual variations - characterized before DNA adducts can be effectively applied as biomarkers;
  • exocyclic-DNA adduct formation - with increasing oxidative stress, by improving DNA repair;
  • inflammation, linked to increased levels of oxidative stress - direct and indirect types of DNA damage;
  • exocyclic DNA adducts, promising intermediate molecular markers - of inflammation-driven human carcinogenesis testing efficacy of chemopreventive agents

Summary

This chapter contains sections titled:

  • Introduction

  • Criteria for DNA Adducts as Biomarkers of Exposure to Oxidative Stress and Lipid Peroxidation Products

  • Comparison of Various Methodologies Reflecting Different Processes in Inflammation-Driven Genotoxicity

  • Summary and Perspectives

  • References