3. Antioxidants as Biomarkers of Oxidative Stress

  1. Giancarlo Aldini3,
  2. Kyung-Jin Yeum4,
  3. Etsuo Niki5 and
  4. Robert M. Russell6
  1. Ikuyo Ichi1 and
  2. Shosuke Kojo2

Published Online: 4 AUG 2010

DOI: 10.1002/9780813814438.ch3

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

How to Cite

Ichi, I. and Kojo, S. (2010) Antioxidants as Biomarkers of Oxidative Stress, in Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (eds G. Aldini, K.-J. Yeum, E. Niki and R. M. Russell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813814438.ch3

Editor Information

  1. 3

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 4

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 5

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

  4. 6

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Author Information

  1. 1

    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan

  2. 2

    Department of Food Science and Nutrition, Nara Women's University, Nara 630-8506, Japan

Publication History

  1. Published Online: 4 AUG 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9780813815350

Online ISBN: 9780813814438

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Keywords:

  • antioxidants as biomarkers of oxidative stress;
  • radical species, designated as X - radical reactions in membrane abstracting hydrogen atom of the lipid (LH);
  • oxidative stress prevention, cell with defense mechanisms - as antioxidants and enzymes;
  • oxidative stress, affecting level of physiological antioxidants - ratio of oxidized/reduced antioxidants;
  • drug-induced hepatitis - model in oxidative stress evaluation;
  • biomarkers of oxidative stress, thiobabituric acid-reactive substances (TBARS) used frequently;
  • ROS, deleterious to biological systems;
  • role of H2O2 - in insulin function;
  • CoQ10 depletion, and disease pathogenesis;
  • antioxidative nutrient decrease in blood and oxidative stress - or as a result of malnutrition

Summary

This chapter contains sections titled:

  • Radical Reactions in the Cell

  • Drug-Induced Hepatitis as a Model to Evaluate Oxidative Stress

  • Virus-Induced Hepatitis in Human Subjects

  • Diabetes in Animals

  • Diabetes in Human Subjects

  • Hemodialysis Patients

  • Ischemia/Reperfusion (I/R) Injury

  • Myocardial Infarction in Human Subjects

  • Leukemia in Human Subjects

  • α-Tocopheryl Quinone

  • Coenzyme Q (CoQ)

  • Concluding Remarks

  • References