4. LDL Oxidation as a Biomarker of Antioxidant Status

  1. Giancarlo Aldini3,
  2. Kyung-Jin Yeum4,
  3. Etsuo Niki5 and
  4. Robert M. Russell6
  1. Mohsen Meydani1,
  2. Eunhee Kong2 and
  3. Ashley Knight1

Published Online: 4 AUG 2010

DOI: 10.1002/9780813814438.ch4

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

How to Cite

Meydani, M., Kong, E. and Knight, A. (2010) LDL Oxidation as a Biomarker of Antioxidant Status, in Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (eds G. Aldini, K.-J. Yeum, E. Niki and R. M. Russell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813814438.ch4

Editor Information

  1. 3

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 4

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 5

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

  4. 6

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Author Information

  1. 1

    Vascular Biology Laboratory, Jean Mayer USDA—Human Nutrition Research Center on Aging, Tufts University, 711 Washington St., Boston, MA 02111, USA

  2. 2

    Department of Family Medicine, College of Medicine, Kosin University, Seo-Gu, Busan, South Korea

Publication History

  1. Published Online: 4 AUG 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9780813815350

Online ISBN: 9780813814438

SEARCH

Keywords:

  • LDL oxidation - as antioxidant status biomarker;
  • atherosclerosis - and vascular response to injury, and vascular wall retention of low density lipoprotein (LDL);
  • oxidatively modified LDL - source of lipids accumulating in atherogenesis;
  • LDL, amounts of cholesterol esters of linoleic and arachidonic acids - in continuous oxidative modification resulting in oxidized product accumulation;
  • LDL oxidation, index of antioxidant status and oxidative stress;
  • organic radical generators and LDL oxidation;
  • cell-mediated oxidation of LDL in vitro;
  • vitamin E, lipid soluble and its antioxidant activity;
  • reports, no correlation between LDL content of vitamin E - and lag time of LDL oxidation;
  • concept of in vitro LDL oxidation - and oxidative hypothesis of atherosclerosis

Summary

This chapter contains sections titled:

  • Introduction

  • LDL Oxidation as an Index of Antioxidant Status and Oxidative Stress

  • Significance of Water-Soluble and Lipid-Soluble Antioxidants to LDL Oxidation

  • The Association of oxLDL and In Vitro LDL Oxidation with Health Status

  • Conclusion

  • Acknowledgement

  • References