6. Hydroxyoctadecadienoic Acid (HODE) as a Marker of Linoleic Acid Oxidation

  1. Giancarlo Aldini2,
  2. Kyung-Jin Yeum3,
  3. Etsuo Niki4 and
  4. Robert M. Russell5
  1. Yasukazu Yoshida1 and
  2. Etsuo Niki4

Published Online: 4 AUG 2010

DOI: 10.1002/9780813814438.ch6

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

How to Cite

Yoshida, Y. and Niki, E. (2010) Hydroxyoctadecadienoic Acid (HODE) as a Marker of Linoleic Acid Oxidation, in Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (eds G. Aldini, K.-J. Yeum, E. Niki and R. M. Russell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813814438.ch6

Editor Information

  1. 2

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 3

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 4

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

  4. 5

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Author Information

  1. 1

    Health Research Institute, National Institute of Advanced Industrial Science and Technology, 2217-14 Hayashi-cho, Takamatsu 761-0395, Japan

  2. 4

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

Publication History

  1. Published Online: 4 AUG 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9780813815350

Online ISBN: 9780813814438

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Keywords:

  • hydroxyoctadecadienoic Acid (HODE) - as linoleic acid oxidation marker;
  • polyunsaturated fatty acids - susceptible to oxidation;
  • biomarker development, for oxidative stress measurement in humans;
  • free linoleic acid and its esters - oxidized by three distinct mechanisms;
  • free radical-mediated linoleate oxidation;
  • antioxidant role - against lipid oxidation;
  • carotenoids, well known quenchers of singlet oxygen;
  • plasma and erythrocytes, separated from whole blood - for tHODE analyses;
  • thiobarbituric reactive substances (TBARS), malonaldehyde (MDA), HODE, isoprostanes and oxysterols;
  • lipid oxidation products, HODE as biomarkers - usefulness and accuracy

Summary

This chapter contains sections titled:

  • Introduction

  • Mechanism and Dynamics of Linoleate Oxidation

  • Role of Antioxidants Against lipid Oxidation

  • Measurement of Hode

  • Assessment of Antioxidant Capacity In Vivo By tHODE

  • tHODE Levels in Healthy Subjects and Diseased Patients

  • tHODE Levels in Animal Experiments

  • Conclusion

  • References