Chapter 7. Oxysterols: Potential Biomarkers of Oxidative Stress

  1. Giancarlo Aldini3,
  2. Kyung-Jin Yeum4,
  3. Etsuo Niki5,
  4. Robert M. Russell6
  1. Luigi Iuliano1,
  2. Ulf Diczfalusy2

Published Online: 4 AUG 2010

DOI: 10.1002/9780813814438.ch7

Book Title

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Additional Information

How to Cite

Iuliano, L. and Diczfalusy, U. (2010) Oxysterols: Potential Biomarkers of Oxidative Stress, in Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (eds G. Aldini, K.-J. Yeum, E. Niki and R. M. Russell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813814438.ch7

Editor Information

  1. 3

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 4

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 5

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

  4. 6

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Author Information

  1. 1

    Sapienza University of Rome, Department of Experimental Medicine, Unit of Vascular Medicine, Vascular Biology and Mass Spectrometry Lab, Corso della Republica 79, 04100 Latina, Italy

  2. 2

    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska University Hospital, Huddinge C1.74 SE-141, 86 Stockholm, Sweden

Publication History

  1. Published Online: 4 AUG 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9780813815350

Online ISBN: 9780813814438

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CHAPTER TOOLS

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Keywords:

  • oxysterols, potential biomarkers of oxidative stress;
  • cholesterol, susceptible to oxidation - forming oxygenated derivatives known as oxysterols;
  • oxysterols, and three different mechanisms - autoxidation, oxidation secondary to lipid peroxidation;
  • oxysterols, transported in human circulation - depending on oxysterol polarity;
  • oxysterol toxicity to cells;
  • oxysterols determination in human plasma - difficult, due to cholesterol in concentration;
  • gas liquid chromatography (GC), widely used method for oxysterol analysis;
  • individual deuterium use - labelled standards, advantage when analyzing multiple oxysterols;
  • oxysterols, markers of oxidative stress - in vitro LDL oxidation;
  • oxysterols, brain cholesterol metabolism key regulators

Summary

This chapter contains sections titled:

  • Introduction

  • Formation of Oxysterols

  • Transport of Oxysterols in the Circulation

  • Toxicity of Oxysterols to Cells

  • Measurment of Oxysterols

  • Oxysterols as Markers of Oxidative Stress

  • Oxysterols and Clinical Conditions

  • Conclusions

  • References

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