8. Lipid Peroxidation Originating α,β-unsaturated Aldehydes and Their Metabolites as Biomarkers

  1. Giancarlo Aldini2,
  2. Kyung-Jin Yeum3,
  3. Etsuo Niki4 and
  4. Robert M. Russell5
  1. Françoise Guéraud

Published Online: 4 AUG 2010

DOI: 10.1002/9780813814438.ch8

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

How to Cite

Guéraud, F. (2010) Lipid Peroxidation Originating α,β-unsaturated Aldehydes and Their Metabolites as Biomarkers, in Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (eds G. Aldini, K.-J. Yeum, E. Niki and R. M. Russell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813814438.ch8

Editor Information

  1. 2

    Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universitàdegli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy

  2. 3

    Jean Mayer USDA—Human Nutrition Research Center on Aging Tufts University, 711 Washington St., Boston, MA 02111 USA

  3. 4

    Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577 Japan

  4. 5

    Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, Maryland 20892 USA

Author Information

  1. INRA Institut National de la Recherche, Argonomigue, UMR 1089 Xénobiotiques BP 93173, 31027 Toulouse Cedex 3, France

Publication History

  1. Published Online: 4 AUG 2010
  2. Published Print: 10 SEP 2010

ISBN Information

Print ISBN: 9780813815350

Online ISBN: 9780813814438

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Keywords:

  • lipid peroxidation originating α,β-unsaturated aldehydes - and metabolites as biomarkers;
  • mercapturic acids (MAs), stable compounds - measured using noninvasive sampling techniques;
  • aldehydes, biomarkers of lipid peroxidation;
  • malondialdehyde (MDA) - first compounds as index of lipid peroxidation;
  • multiple determination - and measurement of multiple aldehydes from lipid peroxidation;
  • tripeptide glutathione (Glu-Cys-Gly) (GSH) - abundant low molecular weight thiol in mammalian cells;
  • mercapturic acids (MAs), S-substituted N-acetyl-L-cysteine derivatives;
  • mercapturic acid pathway (MAP) - major routes of glutathione conjugate excretion;
  • GSH conjugates or MAs - measurement, functional enzymes in transformation steps;
  • GST polymorphism influencing MAs excretion - and occupational exposure to toxic compounds in human studies

Summary

This chapter contains sections titled:

  • Introduction

  • Aldehydes as Biomarkers of Lipid Peroxidation

  • Sources

  • Assay

  • Glutathione Conjugates as Biomarkers of Lipid Peroxidation

  • Mercapturic Acids Derivatives as Biomarkers of Lipid Peroxidation

  • Applications

  • Limitations

  • References