10. Is Hypertension a Disorder of the Brain?

  1. Undurti N. Das MD, PhD, FAMS President CEO Editor-in-Chief1,2

Published Online: 15 JAN 2010

DOI: 10.1002/9780813820637.ch10

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

How to Cite

Das, U. N. (2010) Is Hypertension a Disorder of the Brain?, in Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813820637.ch10

Author Information

  1. 1

    UND Life Sciences, Ohio, USA

  2. 2

    Lipids in Health and Disease, USA

Publication History

  1. Published Online: 15 JAN 2010
  2. Published Print: 19 FEB 2010

ISBN Information

Print ISBN: 9780813815534

Online ISBN: 9780813820637

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Keywords:

  • hypertension, as disorders of brain;
  • nucleus tractus solitarius (NTS) in brain stem medulla;
  • blood pressure regulation - blood volume, heart rate, sympathetic and parasympathetic nervous systems;
  • deep brain stimulation (DBS) - effective therapy for brain disorders;
  • NO synthase (NOS) activity in brain, kidney, endothelium and hypertension;
  • reduced hypothalamic NOS - hypertension without altering hypothalamic blood flow;
  • hypothalamic NO regulating sympathetic outflow;
  • glutamate, role in sympathetic nerve activity regulation;
  • steroid-induced hypertension and hypothalamus;
  • exercise enhancing hypothalamic NOS activity

Summary

This chapter contains sections titled:

  • NO Synthase (NOS) Activity in the Brain, Kidney, and Endothelium and Its Relationship to Hypertension

  • Reduced Hypothalamic NOS Produces Hypertension without Altering Hypothalamic Blood Flow

  • Hypothalamic NO Regulates Sympathetic Outflow

  • Steroid-induced Hypertension and Hypothalamus

  • Exercise Enhances Hypothalamic NOS Activity

  • Both Hypertension and Type 2 Diabetes Mellitus and Hence the Metabolic Syndrome Are Disorders of the Brain

  • References