13. Insulin and Insulin Receptors in the Brain and Their Role in the Pathogenesis of Obesity and Type 2 Diabetes Mellitus

  1. Undurti N. Das MD, PhD, FAMS President CEO Editor-in-Chief1,2

Published Online: 15 JAN 2010

DOI: 10.1002/9780813820637.ch13

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

How to Cite

Das, U. N. (2010) Insulin and Insulin Receptors in the Brain and Their Role in the Pathogenesis of Obesity and Type 2 Diabetes Mellitus, in Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813820637.ch13

Author Information

  1. 1

    UND Life Sciences, Ohio, USA

  2. 2

    Lipids in Health and Disease, USA

Publication History

  1. Published Online: 15 JAN 2010
  2. Published Print: 19 FEB 2010

ISBN Information

Print ISBN: 9780813815534

Online ISBN: 9780813820637

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Keywords:

  • insulin and insulin receptors in brain;
  • insulin - regulating glucose metabolism and protein and fat metabolism;
  • insulin signaling - food intake regulation and neuronal growth and differentiation;
  • glucose transporters and glucokinase in hypothalamus;
  • Neuron-specific Disruption of the Insulin Receptor Gene (NIRKO);
  • insulin and hypothalamic neuropeptides;
  • leptin receptors on pancreatic β cells;
  • activation of ATP-sensitive potassium (K(ATP)) channels in mediobasal hypothalamus - lowering blood glucose levels;
  • GLP-1 administration - normalizing hyperglycemia of non-insulin-dependent diabetes mellitus (NIDDM);
  • GLP-1, potent stimulator of glucose-induced insulin secretion and human physiology actions

Summary

This chapter contains sections titled:

  • Insulin and Insulin Receptors in the Brain

  • Glucose Transporters and Glucokinase in Hypothalamus

  • Neuron-specific Disruption of the Insulin Receptor Gene (NIRKO)

  • Insulin and Hypothalamic Neuropeptides

  • Leptin Receptors on Pancreatic β Cells

  • Glucagon-like Peptide, Insulin, and the Metabolic Syndrome

  • References