14. Insulin, Endothelial Nitric Oxide, and the Metabolic Syndrome

  1. Undurti N. Das MD, PhD, FAMS President CEO Editor-in-Chief1,2

Published Online: 15 JAN 2010

DOI: 10.1002/9780813820637.ch14

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

How to Cite

Das, U. N. (2010) Insulin, Endothelial Nitric Oxide, and the Metabolic Syndrome, in Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813820637.ch14

Author Information

  1. 1

    UND Life Sciences, Ohio, USA

  2. 2

    Lipids in Health and Disease, USA

Publication History

  1. Published Online: 15 JAN 2010
  2. Published Print: 19 FEB 2010

ISBN Information

Print ISBN: 9780813815534

Online ISBN: 9780813820637

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Keywords:

  • insulin, endothelial nitric oxide, and metabolic syndrome;
  • plasma concentrations of pro-inflammatory markers - in obesity;
  • insulin resistance and glucose metabolism deficits;
  • insulin activating endothelial nitric oxide synthase (eNOS) by protein kinase B (PKB)-mediated phosphorylation;
  • atherosclerosis, beginning before insulin resistance occurrence;
  • cross-talk between insulin and renin-angiotensin-aldosterone system;
  • hypertension - in obesity and type 2 diabetes mellitus;
  • human umbilical vein endothelial cells (HUVECs);
  • pro-inflammatory cytokines and insulin resistance;
  • growth hormone secretagogue receptors (GHSRs) in hypothalamic neurons

Summary

This chapter contains sections titled:

  • Insulin Resistance and Nitric Oxide

  • Ghrelin Improves Endothelial Function in the Metabolic Syndrome

  • Cross-talk between Insulin and Renin-Angiotensin-Aldosterone System

  • Pro-inflammatory Cytokines Produce Insulin Resistance

  • References