19. EFAs/PUFAs and Their Metabolites in Insulin Resistance

  1. Undurti N. Das MD, PhD, FAMS President CEO Editor-in-Chief1,2

Published Online: 15 JAN 2010

DOI: 10.1002/9780813820637.ch19

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

How to Cite

Das, U. N. (2010) EFAs/PUFAs and Their Metabolites in Insulin Resistance, in Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813820637.ch19

Author Information

  1. 1

    UND Life Sciences, Ohio, USA

  2. 2

    Lipids in Health and Disease, USA

Publication History

  1. Published Online: 15 JAN 2010
  2. Published Print: 19 FEB 2010

ISBN Information

Print ISBN: 9780813815534

Online ISBN: 9780813820637

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Keywords:

  • EFAs/PUFAs and metabolites in insulin resistance;
  • essential fatty acids (EFAs)/polyunsaturated fatty acids (PUFAs) in insulin resistance;
  • GLUT-4 in insulin resistance;
  • hyperglycemia inducing oxidative stress - adiponectin and insulin level depletion;
  • tumor necrosis factor-α (TNF-α) and insulin resistance;
  • neurosecretory signaling system of Caenorhabditis elegans - reproductive life cycle regulation;
  • PUFAs in reducing insulin resistance - PUFA effects on nuclear receptors in lipogenesis regulation;
  • PUFAs, daf genes, PPARs, and Sirtuins - clinical implications of their interaction;
  • diet restriction, daf-genes, and glucose homeostasis interactions;
  • Southeast Asians, abdominal obesity - inherent abnormality in EFAs/PUFAs metabolism

Summary

This chapter contains sections titled:

  • GLUT-4 in Insulin Resistance

  • Tumor Necrosis Factor Induces Insulin Resistance

  • Caloric Restriction Influences Insulin Signaling Pathway, Antioxidants, daf genes, PTEN, Sirtuins (Silent Mating Type Information Regulation 2 Homologue), and Longevity and Their Relationship to Insulin Resistance

  • PUFAs Can Reduce Insulin Resistance

  • PUFAs, GLUT-4, TNF-α, Anti-oxidants, daf Genes, SIRT1, and PPARs

  • Clinical Implications of the Interactions among PUFAs, daf Genes, PPARs, and Sirtuins

  • References