8. Essential Hypertension

  1. Undurti N. Das MD, PhD, FAMS President CEO Editor-in-Chief1,2

Published Online: 15 JAN 2010

DOI: 10.1002/9780813820637.ch8

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids

How to Cite

Das, U. N. (2010) Essential Hypertension, in Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780813820637.ch8

Author Information

  1. 1

    UND Life Sciences, Ohio, USA

  2. 2

    Lipids in Health and Disease, USA

Publication History

  1. Published Online: 15 JAN 2010
  2. Published Print: 19 FEB 2010

ISBN Information

Print ISBN: 9780813815534

Online ISBN: 9780813820637



  • essential hypertension;
  • hypertension, major components of metabolic syndrome;
  • hypertension - risk factors for coronary heart disease (CHD), stroke, atherosclerosis, and peripheral vascular disease (PVD);
  • free radicals in hypertension pathobiology;
  • endothelium-derived hyperpolarizing factor (EHF);
  • hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor;
  • superoxide anion production increase in hypertension;
  • NO role in hypertension;
  • selective defect in NO synthesis - presence in hypertension;
  • antihypertensive drugs and superoxide anion suppression - enhancing NO generation


This chapter contains sections titled:

  • Prevalence and Incidence of Hypertension

  • Free Radicals in the Pathobiology of Hypertension

  • Increase in Superoxide Anion Production in Hypertension: How and Why?

  • Mechanism(s) of Induction of Hypertension by Superoxide Anion

  • Role of NO in Hypertension

  • Salt, Cyclosporine, and Calcium Modulate O2−⋅ and Endothelial NO Generation

  • l-Arginine, NO, and Asymmetrical Dimethylarginine in Hypertension and Pre-eclampsia

  • Antihypertensive Drugs Suppress Superoxide Anion and Enhance NO Generation

  • Transforming Growth Factor-β, NO, and Hypertension

  • References